A practical procedure for real-time functional mapping of eloquent cortex using electrocorticographic signals in humans.

TitleA practical procedure for real-time functional mapping of eloquent cortex using electrocorticographic signals in humans.
Publication TypeJournal Article
Year of Publication2009
AuthorsBrunner, P, Ritaccio, AL, Lynch, TM, Emrich, JF, Wilson, AJ, Williams, JC, Aarnoutse, EJ, Ramsey, NF, Leuthardt, EC, Bischof, H, Schalk, G
JournalEpilepsy Behav
Volume15
Issue3
Pagination278-86
Date Published07/2009
ISSN1525-5069
KeywordsAdult, Brain Mapping, Cerebral Cortex, Electric Stimulation, Electrodes, Implanted, Electroencephalography, Epilepsy, Female, Humans, Male, Middle Aged, Practice Guidelines as Topic, Signal Processing, Computer-Assisted, Young Adult
Abstract Functional mapping of eloquent cortex is often necessary prior to invasive brain surgery, but current techniques that derive this mapping have important limitations. In this article, we demonstrate the first comprehensive evaluation of a rapid, robust, and practical mapping system that uses passive recordings of electrocorticographic signals. This mapping procedure is based on the BCI2000 and SIGFRIED technologies that we have been developing over the past several years. In our study, we evaluated 10 patients with epilepsy from four different institutions and compared the results of our procedure with the results derived using electrical cortical stimulation (ECS) mapping. The results show that our procedure derives a functional motor cortical map in only a few minutes. They also show a substantial concurrence with the results derived using ECS mapping. Specifically, compared with ECS maps, a next-neighbor evaluation showed no false negatives, and only 0.46 and 1.10% false positives for hand and tongue maps, respectively. In summary, we demonstrate the first comprehensive evaluation of a practical and robust mapping procedure that could become a new tool for planning of invasive brain surgeries.
URLhttp://www.ncbi.nlm.nih.gov/pubmed/19366638
DOI10.1016/j.yebeh.2009.04.001
Alternate JournalEpilepsy Behav
PubMed ID19366638
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