Localizing ECoG electrodes on the cortical anatomy without post-implantation imaging.

TitleLocalizing ECoG electrodes on the cortical anatomy without post-implantation imaging.
Publication TypeJournal Article
Year of Publication2014
AuthorsGupta, D, Hill, N Jeremy, Adamo, MA, Ritaccio, A, Schalk, G
JournalNeuroimage Clin
Volume6
Pagination64-76
Date Published08/2014
ISSN2213-1582
Abstract

INTRODUCTION: Electrocorticographic (ECoG) grids are placed subdurally on the cortex in people undergoing cortical resection to delineate eloquent cortex. ECoG signals have high spatial and temporal resolution and thus can be valuable for neuroscientific research. The value of these data is highest when they can be related to the cortical anatomy. Existing methods that establish this relationship rely either on post-implantation imaging using computed tomography (CT), magnetic resonance imaging (MRI) or X-Rays, or on intra-operative photographs. For research purposes, it is desirable to localize ECoG electrodes on the brain anatomy even when post-operative imaging is not available or when intra-operative photographs do not readily identify anatomical landmarks.

METHODS: We developed a method to co-register ECoG electrodes to the underlying cortical anatomy using only a pre-operative MRI, a clinical neuronavigation device (such as BrainLab VectorVision), and fiducial markers. To validate our technique, we compared our results to data collected from six subjects who also had post-grid implantation imaging available. We compared the electrode coordinates obtained by our fiducial-based method to those obtained using existing methods, which are based on co-registering pre- and post-grid implantation images.

RESULTS: Our fiducial-based method agreed with the MRI-CT method to within an average of 8.24 mm (mean, median = 7.10 mm) across 6 subjects in 3 dimensions. It showed an average discrepancy of 2.7 mm when compared to the results of the intra-operative photograph method in a 2D coordinate system. As this method does not require post-operative imaging such as CTs, our technique should prove useful for research in intra-operative single-stage surgery scenarios. To demonstrate the use of our method, we applied our method during real-time mapping of eloquent cortex during a single-stage surgery. The results demonstrated that our method can be applied intra-operatively in the absence of post-operative imaging to acquire ECoG signals that can be valuable for neuroscientific investigations.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/25379417
DOI10.1016/j.nicl.2014.07.015
Alternate JournalNeuroimage Clin
PubMed ID25379417
PubMed Central IDPMC4215521
Grant ListEB000856 / EB / NIBIB NIH HHS / United States
EB006356 / EB / NIBIB NIH HHS / United States
P41 EB018783 / EB / NIBIB NIH HHS / United States
R01 EB000856 / EB / NIBIB NIH HHS / United States
© 2017
If you are a registered member of the lab, you may log in here.