Simultaneous real-time monitoring of multiple cortical systems.

TitleSimultaneous real-time monitoring of multiple cortical systems.
Publication TypeJournal Article
Year of Publication2014
AuthorsGupta, D, Hill, N Jeremy, Brunner, P, Gunduz, A, Ritaccio, AL, Schalk, G
JournalJ Neural Eng
Volume11
Issue5
Pagination056001
Date Published2014 Jul 31
ISSN1741-2552
Keywordsauditory processing, Electrocorticography, movement intention, real-time decoding, simultaneous decoding
Abstract

Objective. Real-time monitoring of the brain is potentially valuable for performance monitoring, communication, training or rehabilitation. In natural situations, the brain performs a complex mix of various sensory, motor or cognitive functions. Thus, real-time brain monitoring would be most valuable if (a) it could decode information from multiple brain systems simultaneously, and (b) this decoding of each brain system were robust to variations in the activity of other (unrelated) brain systems. Previous studies showed that it is possible to decode some information from different brain systems in retrospect and/or in isolation. In our study, we set out to determine whether it is possible to simultaneously decode important information about a user from different brain systems in real time, and to evaluate the impact of concurrent activity in different brain systems on decoding performance. Approach. We study these questions using electrocorticographic signals recorded in humans. We first document procedures for generating stable decoding models given little training data, and then report their use for offline and for real-time decoding from 12 subjects (six for offline parameter optimization, six for online experimentation). The subjects engage in tasks that involve movement intention, movement execution and auditory functions, separately, and then simultaneously. Main results. Our real-time results demonstrate that our system can identify intention and movement periods in single trials with an accuracy of 80.4% and 86.8%, respectively (where 50% would be expected by chance). Simultaneously, the decoding of the power envelope of an auditory stimulus resulted in an average correlation coefficient of 0.37 between the actual and decoded power envelopes. These decoders were trained separately and executed simultaneously in real time. Significance. This study yielded the first demonstration that it is possible to decode simultaneously the functional activity of multiple independent brain systems. Our comparison of univariate and multivariate decoding strategies, and our analysis of the influence of their decoding parameters, provides benchmarks and guidelines for future research on this topic.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/25080161
DOI10.1088/1741-2560/11/5/056001
Alternate JournalJ Neural Eng
PubMed ID25080161
PubMed Central IDPMC4175132
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